Regenerative aesthetics is revolutionizing the medical aesthetic practice, offering minimally invasive solutions that harness the body’s innate healing power. Among the most exciting advancements are polynucleotides (PN) and exosomes—two cutting-edge treatments gaining traction for their ability to rejuvenate skin, accelerate healing, and deliver natural-looking results. But with great hype comes great responsibility. As clinicians and researchers, we’ve seen patients confused by bold marketing claims.  So, what exactly are they? How do they work? And are they safe?
In this blog, we’ll dive into the science, clinical applications, and latest data behind these therapies, equipping you with evidence-based insights to make informed decisions.

Part 1: Polynucleotides – The DNA-Based Skin Regenerators

What Are Polynucleotides?Polynucleotides (PN) are biostimulatory molecules composed of long chains of nucleotides—the building blocks of DNA and RNA. Sourced from salmon or synthetic DNA, these fragments are purified to remove allergenic proteins, leaving behind biocompatible polymers that act as signaling molecules. When injected into the skin, PN triggers fibroblast activation, collagen synthesis, and tissue repair.

Clinical Uses

1. Skin Rejuvenation: PN stimulates collagen type I and III production, improving elasticity and reducing fine lines. A 2023 study in Aesthetic Surgery Journal reported a 68% improvement in skin hydration and a 42% reduction in wrinkles after three PN sessions.

Pro Tip: PN is exceptional for under-eye rejuvenation. Its osmotic effect reduces fluid retention and thickens thin eyelid skin. It also has a highly rejuvenating effect on the perioral area.

2. Wound Healing:  PN isn’t just for aesthetics. PN accelerates tissue repair by modulating inflammation and promoting angiogenesis. It’s used post-laser therapy or surgery to minimize downtime. A 2023 trial showed PN-treated burns healed 30% faster vs. standard care.

Safety and Efficacy

• Safety: PN is hypoallergenic and biocompatible. Side effects are rare (<5% of cases) and mild (redness, swelling).

• Efficacy: Results last 6–12 months. A meta-analysis of 1,200 patients (2023) showed 89% satisfaction rates for skin texture improvement.

Part 2: Exosomes – The Next Frontier in Cellular Communication

What Are Exosomes?

Exosomes are nano-sized extracellular vesicles (30–150 nm) released by stem cells. They’re packed with 300+ bioactive molecules: growth factors (TGF-β, VEGF), mRNA, and enzymes. They act as cellular “messengers,” instructing aging or damaged cells to regenerate. Unlike stem cells, exosomes don’t replicate, making them safer and easier to regulate.

Clinical Uses

1. Anti-Aging: Exosomes restore fibroblast function, boosting collagen and elastin. A 2024 Korean study demonstrated a 55% improvement in skin firmness after two treatments.

2. Scar Revision: Their anti-inflammatory properties soften hypertrophic scars. In a 2023 trial, 78% of acne scar patients saw visible improvement within eight weeks.

3. Post-Procedure Recovery: Exosomes reduce downtime after lasers or microneedling by 50%, per a 2024 Journal of Cosmetic Dermatology review.

4. Hair growth: Exosomes contain growth factors that stimulate dormant hair follicles. In addition to that they increase small blood vessels formation that are very essential for hair follicles.

Safety and Efficacy

• Safety: Exosome therapy is low-risk, but sourcing matters. Only FDA-compliant, pathogen-free exosomes should be used. No severe adverse events have been reported in peer-reviewed studies. Always ask for certificates of analysis (COA).

• Efficacy: Results appear in 2–4 weeks and last up to a year. A 2023 multicenter study noted 92% patient satisfaction for overall skin quality.

 

Comparing Polynucleotides vs. Exosomes

Safety First: What the Data Says

Both therapies are considered safe, but caveats exist:

• Polynucleotides:

Ensure ultra-purified PN to remove proteins (reduces allergy risk).

Start with a patch test for seafood-allergic patients (though most salmon DNA is non-allergenic after processing).

• Exosomes:

Source Matters: Ensure clinics use products screened for endotoxins and viral contaminants. The FDA warns against unregulated “stem cell” clinics offering exosomes—always verify sourcing.

Mesenchymal stem cell (MSC)-derived exosomes from umbilical cord or adipose tissue are gold standard, but further safety studies are needed. Plant-based exosomes are still the safest. Avoid “placental” exosomes—often contaminated.

Storage: Exosomes must be frozen at -80°C. If a clinic stores them in a fridge, walk away.

The Future: What’s Next?

• Personalized Exosomes: Labs are engineering exosomes loaded with custom miRNAs to target specific genes (e.g., APOE for aging).

• PN + Exosome Cocktails: Early studies show that combining PN’s structural support with exosomes’ reprogramming power yields longer-lasting results.

• Homecare Synergy: Brands like Neogenesis and AnteAge now sell topical exosome serums to extend in-office results.

Polynucleotides and exosomes represent a paradigm shift in regenerative aesthetics, offering science-backed solutions with minimal risk and downtime. While PN excels in hydration and tissue repair, exosomes shine in cellular rejuvenation and scar revision.

As with any treatment, success hinges on expertise. At Georges Ziade Clinics, we use only rigorously tested products with the longest safety profile and tailor protocols to your unique needs. Interested in learning more? Schedule a consultation to explore how these innovations can help you achieve your aesthetic goals.

The future of beauty isn’t just about looking younger—it’s about harnessing your body’s innate power to heal.

Our News:

Mrs. Andrea joined Dr. George Ziade’s Team!

• We are delighted to welcome Mrs. Andreea Michaela, our new senior beauty & laser therapy specialist, a highly experienced beauty and laser therapist. With over 30 years in aesthetics and 24 years in Dubai, she brings specialized expertise and the latest solutions in advanced laser and skin treatments, including skin rejuvenation, acne and scar reduction, and vascular lesion therapies. She committed to providing our patients with the latest and most effective aesthetic solutions.

Introducing Our Luxurious Gift Box

• Present the gift of beauty and self-care with our new luxurious gift box. This exquisite offering allows your loved ones to indulge in our premium facials, skin rejuvenation, or any aesthetic treatment, a truly thoughtful expression of care, wrapped in utmost luxury! Gift Boxes are available for purchase at our clinics.

Carole Achieves American Board Trainer Certification

• Congratulations to Carole, our esteemed Lebanese beauty therapist, on receiving the prestigious title of Trainer from the American Board. This recognition highlights her exceptional skill and expertise in the field.

Dr. Ziade Presents at IMCAS Paris 2025

• Dr. George Ziade delivered a compelling lecture at IMCAS Paris 2025, titled “5 Years Experience with Polynucleotides,” sharing valuable insights from our clinic’s extensive experience with Salmon purified DNA injections.

Valentine’s Open Day in Lebanon

• Our recent Valentine’s Open Day in Lebanon, in partnership with Vichy and CeraVe, was a resounding success, offering attendees exclusive insights and promotions.

Mother’s Day Open Day Celebrated with Exocobio

• We held a very successful mothers day open day in Lebanon with Exocobio(Exosome) showing the newest technology in skin rejuvenation.